Drug Use In Pregnancy — Douglas Ong. File last modified 6 April 2018; the chart on slides 7–8 is dated January 2009. These are source dates, not a clinical review date.
Both filters can be combined. Topic headings reproduce the source organisation; a medicine appearing under a topic is not a treatment recommendation. Brand formulations may have changed. Historical entries remain searchable in breastfeeding mode, but cannot answer breastfeeding safety.
Enter a medicine or choose a topic to begin.
Acetaminophen Historical reference only Brand name in source：Tylenol
Douglas Ong · Slide 2 · Pain / fever
Original statement and legacy category Historical source statement; not current advice:
Pain reliever of choice Legacy category B/B/B Placental passage in source Yes Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Advil; Motrin
Douglas Ong · Slide 2 · Pain / fever
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Use with caution; avoid in third trimester Legacy category B/B/D Placental passage in source Yes Breastfeeding Not assessed in this source
Ketoprofen Historical reference only Brand name in source：Orudis
Douglas Ong · Slide 2 · Pain / fever
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Use with caution; avoid in third trimester Legacy category B/B/D Placental passage in source Yes Breastfeeding Not assessed in this source
Naproxen Historical reference only Brand name in source：Aleve
Douglas Ong · Slide 2 · Pain / fever
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Use with caution; avoid in third trimester Legacy category B/B/D Placental passage in source Yes Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Not specified
Douglas Ong · Slide 2 · Pain / fever
Source restriction (original)： Footnote lists perinatal mortality, neonatal hemorrhage, decreased birth weight, prolonged gestation/labor and possible teratogenicity.
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Not recommended except for specific indications Legacy category D/D/D Placental passage in source Yes Breastfeeding Not assessed in this source
Chlorpheniramine Historical reference only Brand name in source：Chlor-Trimeton
Douglas Ong · Slide 3 · Cold, cough / allergy
Original statement and legacy category Historical source statement; not current advice:
Antihistamine of choice Legacy category B Placental passage in source Not known Breastfeeding Not assessed in this source
Pseudoephedrine hydrochloride Historical reference only Brand name in source：Novafed
Douglas Ong · Slide 3 · Cold, cough / allergy
Selected update · checked 26 Oct 2026 Current NHS guidance does not recommend pseudoephedrine in pregnancy; this differs from the old “of choice” wording.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Oral decongestant of choice; possible association with gastroschisis Legacy category B Placental passage in source Not known Breastfeeding Not assessed in this source
Guaifenesin Historical reference only Brand name in source：Humibid L.A.
Douglas Ong · Slide 3 · Cold, cough / allergy
Source restriction (original)： Possible increased risk of neural tube defects (slide footnote).
Original statement and legacy category Historical source statement; not current advice:
May be unsafe in first trimester Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Dextromethorphan hydrobromide Historical reference only Brand name in source：Benylin DM
Douglas Ong · Slide 3 · Cold, cough / allergy
Original statement and legacy category Historical source statement; not current advice:
Appears to be safe in pregnancy Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Diphenhydramine Historical reference only Brand name in source：Benadryl
Douglas Ong · Slide 3 · Cold, cough / allergy
Original statement and legacy category Historical source statement; not current advice:
Possible oxytocin-like effects at high dosages Legacy category B Placental passage in source Yes Breastfeeding Not assessed in this source
Clemastine fumarate Historical reference only Brand name in source：Tavist
Douglas Ong · Slide 3 · Cold, cough / allergy
Original statement and legacy category Historical source statement; not current advice:
Unknown safety profile Legacy category B Placental passage in source Not known Breastfeeding Not assessed in this source
Kaolin and pectin Historical reference only Brand name in source：Kaopectate
Douglas Ong · Slide 4 · Diarrhoea
Original statement and legacy category Historical source statement; not current advice:
Antidiarrheal of choice (not absorbed) Legacy category B/B/B Placental passage in source No Breastfeeding Not assessed in this source
Bismuth subsalicylate Historical reference only Brand name in source：Pepto Bismol
Douglas Ong · Slide 4 · Diarrhoea
Original statement and legacy category Historical source statement; not current advice:
Not recommended (salicylate absorption) Legacy category C/C/D Placental passage in source Yes Breastfeeding Not assessed in this source
Loperamide Historical reference only Brand name in source：Imodium
Douglas Ong · Slide 4 · Diarrhoea
Source restriction (original)： Possible increase in fetal cardiac malformation with first-trimester use (slide footnote).
Selected update · checked 26 Oct 2026 Current NHS guidance does not usually recommend loperamide in pregnancy because evidence is limited.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Probably safe Legacy category B/B/B Placental passage in source Not known Breastfeeding Not assessed in this source
Atropine/diphenoxylate Historical reference only Brand name in source：Lomotil
Douglas Ong · Slide 4 · Diarrhoea
Original statement and legacy category Historical source statement; not current advice:
Not recommended (adverse animal studies) Legacy category C/C/C Placental passage in source Not known Breastfeeding Not assessed in this source
Aluminum hydroxide/magnesium hydroxide Historical reference only Brand name in source：Maalox
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Source restriction (original)： Slide footnote says “Contains magnesium sulfate”; formulation requires verification.
Original statement and legacy category Historical source statement; not current advice:
Generally regarded as safe Legacy category B Placental passage in source Not known Breastfeeding Not assessed in this source
Calcium carbonate Historical reference only Brand name in source：Tums
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Generally regarded as safe Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Simethicone Historical reference only Brand name in source：Mylanta Gas
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Generally regarded as safe Legacy category C Placental passage in source No Breastfeeding Not assessed in this source
Cimetidine Historical reference only Brand name in source：Tagamet
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Preferred after antacids; generally regarded as safe Legacy category B Placental passage in source Yes Breastfeeding Not assessed in this source
Ranitidine Historical reference only Brand name in source：Zantac
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Selected update · checked 26 Oct 2026 Ranitidine products have been subject to NDMA-related regulatory action. Verify the current local product and active ingredient; this old Zantac entry does not establish availability or suitability.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Preferred after antacids; generally regarded as safe Legacy category B Placental passage in source Yes Breastfeeding Not assessed in this source
Nizatidine Historical reference only Brand name in source：Axid
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Selected update · checked 26 Oct 2026 Current UKTIS/BUMPS guidance allows consideration of H2 blockers if other acid treatments are unsuitable. The old blanket statement is not current prescribing advice.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Not recommended (adverse animal studies) Legacy category C Placental passage in source Yes Breastfeeding Not assessed in this source
Famotidine Historical reference only Brand name in source：Pepcid
Douglas Ong · Slide 5 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Probably safe, data needed Legacy category B Placental passage in source Yes Breastfeeding Not assessed in this source
Butoconazole Historical reference only Brand name in source：Femstat
Douglas Ong · Slide 6 · Vaginal fungal infection
Source restriction (original)： Topical vaginal formulations only.
Original statement and legacy category Historical source statement; not current advice:
Probably safe Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Clotrimazole Historical reference only Brand name in source：Lotrimin
Douglas Ong · Slide 6 · Vaginal fungal infection
Source restriction (original)： Topical vaginal formulations only.
Original statement and legacy category Historical source statement; not current advice:
Safe in second and third trimesters (human trials); first trimester probably safe Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Miconazole Historical reference only Brand name in source：Monistat
Douglas Ong · Slide 6 · Vaginal fungal infection
Source restriction (original)： Topical vaginal formulations only.
Original statement and legacy category Historical source statement; not current advice:
Probably safe Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Tioconazole Historical reference only Brand name in source：Vagistat-1
Douglas Ong · Slide 6 · Vaginal fungal infection
Source restriction (original)： Topical vaginal formulations only.
Original statement and legacy category Historical source statement; not current advice:
No data Legacy category C Placental passage in source Not known Breastfeeding Not assessed in this source
Niacin extended-release/lovastatin Historical reference only Brand name in source：Advicor
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Lovastatin Historical reference only Brand name in source：Altoprev
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Bayer
Douglas Ong · Slide 7 · Cardiovascular chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Amlodipine/atorvastatin Historical reference only Brand name in source：Caduet
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Warfarin sodium Historical reference only Brand name in source：Coumadin
Douglas Ong · Slide 7 · Cardiovascular chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Rosuvastatin Historical reference only Brand name in source：Crestor
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Ecotrin
Douglas Ong · Slide 7 · Cardiovascular chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Fluvastatin Historical reference only Brand name in source：Lescol; Lescol XL
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Atorvastatin Historical reference only Brand name in source：Lipitor
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Lovastatin Historical reference only Brand name in source：Mevacor
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Pravastatin Historical reference only Brand name in source：Pravachol
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Buffered aspirin/pravastatin Historical reference only Brand name in source：Pravigard PAC
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ezetimibe/simvastatin Historical reference only Brand name in source：Vytorin
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Simvastatin Historical reference only Brand name in source：Zocor
Douglas Ong · Slide 7 · Cardiovascular chart
Selected update · checked 26 Oct 2026 FDA removed the blanket strongest pregnancy contraindication for statins in 2021, but still advises most pregnant patients to stop them under clinical guidance. Individual high-risk exceptions require a specialist.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Flurazepam hydrochloride Historical reference only Brand name in source：Dalmane
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Quazepam Historical reference only Brand name in source：Doral
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Estazolam Historical reference only Brand name in source：Estazolam
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Triazolam Historical reference only Brand name in source：Halcion
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Temazepam Historical reference only Brand name in source：Restoril
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Drospirenone/ethinyl estradiol Historical reference only Brand name in source：Yaz
Douglas Ong · Slide 7 · Nervous system chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Isotretinoin Historical reference only Brand name in source：Accutane
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Tazarotene Historical reference only Brand name in source：Avage
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Fluorouracil Historical reference only Brand name in source：Carac; Efudex
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Norethindrone acetate/ethinyl estradiol Historical reference only Brand name in source：Estrostep Fe
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Norgestimate/ethinyl estradiol Historical reference only Brand name in source：Ortho Tri-Cyclen 28
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Finasteride Historical reference only Brand name in source：Propecia
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Mequinol/tretinoin Historical reference only Brand name in source：Solage
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac sodium Historical reference only Brand name in source：Solaraze
Douglas Ong · Slide 7 · Dermatology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Acitretin Historical reference only Brand name in source：Soriatane
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Silver sulfadiazine Historical reference only Brand name in source：SSD; SSD AF
Douglas Ong · Slide 7 · Dermatology chart
Source restriction (original)： Late pregnancy
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Tazarotene Historical reference only Brand name in source：Tazorac
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Norgestimate/ethinyl estradiol Historical reference only Brand name in source：Tri-previfem; Tri-sprintec
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Drospirenone/ethinyl estradiol Historical reference only Brand name in source：Yaz
Douglas Ong · Slide 7 · Dermatology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Testosterone Historical reference only Brand name in source：Androderm; Androgel
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Methyltestosterone Historical reference only Brand name in source：Android
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Testosterone enanthate Historical reference only Brand name in source：Delatestryl
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Testosterone cypionate Historical reference only Brand name in source：Depo-testosterone
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Leuprolide acetate Historical reference only Brand name in source：Lupron
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Methyltestosterone Historical reference only Brand name in source：Methitest
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Oxandrolone Historical reference only Brand name in source：Oxandrin
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Testosterone Historical reference only Brand name in source：Striant
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Histrelin acetate Historical reference only Brand name in source：Supprelin LA
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nafarelin Historical reference only Brand name in source：Synarel
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Testosterone Historical reference only Brand name in source：Testim
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Methyltestosterone Historical reference only Brand name in source：Testred; Virilon
Douglas Ong · Slide 7 · Endocrine chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Phenobarbital/ergotamine tartrate Historical reference only Brand name in source：Bellergal-S
Douglas Ong · Slide 7 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Misoprostol Historical reference only Brand name in source：Cytotec
Douglas Ong · Slide 7 · Reflux / gastrointestinal topics
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ribavirin Historical reference only Brand name in source：Copegus
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Metronidazole Historical reference only Brand name in source：Flagyl
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： 1st trimester for trichomoniasis
Selected update · checked 26 Oct 2026 CDC guidance recommends testing and treating symptomatic pregnant patients with trichomoniasis regardless of pregnancy stage. Do not apply the old first-trimester prohibition without current clinical review.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Sulfisoxazole Historical reference only Brand name in source：Gantrisin
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Griseofulvin Historical reference only Brand name in source：Grifulvin V
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nitrofurantoin (macrocrystals and monohydrate) Historical reference only Brand name in source：Macrobid
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： Pregnancy at term
Selected update · checked 26 Oct 2026 Nitrofurantoin can be used earlier in pregnancy when indicated; later pregnancy needs a clinician’s risk assessment because of newborn red-cell concerns. This is not an all-pregnancy prohibition.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nitrofurantoin Historical reference only Brand name in source：Macrodantin
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： Pregnancy at term
Selected update · checked 26 Oct 2026 Nitrofurantoin can be used earlier in pregnancy when indicated; later pregnancy needs a clinician’s risk assessment because of newborn red-cell concerns. This is not an all-pregnancy prohibition.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Erythromycin/sulfisoxazole Historical reference only Brand name in source：Pediazole
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ribavirin Historical reference only Brand name in source：Rebetol
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ribavirin/interferon alfa-2b Historical reference only Brand name in source：Rebetron
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Tinidazole Historical reference only Brand name in source：Tindamax
Douglas Ong · Slide 7 · Infection chart
Source restriction (original)： 1st trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ribavirin Historical reference only Brand name in source：Virazole
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nelfinavir mesylate Historical reference only Brand name in source：Viracept
Douglas Ong · Slide 7 · Infection chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Advil
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Naproxen sodium Historical reference only Brand name in source：Aleve
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Flurbiprofen Historical reference only Brand name in source：Ansaid
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Leflunomide Historical reference only Brand name in source：Arava
Douglas Ong · Slide 7 · Musculoskeletal chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac sodium/misoprostol Historical reference only Brand name in source：Arthrotec
Douglas Ong · Slide 7 · Musculoskeletal chart
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Bayer
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac potassium Historical reference only Brand name in source：Cataflam
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Celecoxib Historical reference only Brand name in source：Celebrex
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Choline magnesium trisalicylate Historical reference only Brand name in source：Choline magnesium trisalicylate
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Pregnancy at term
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Dantrolene Historical reference only Brand name in source：Dantrium
Douglas Ong · Slide 7 · Musculoskeletal chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Oxaprozin Historical reference only Brand name in source：Daypro
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diflunisal Historical reference only Brand name in source：Diflunisal
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Ecotrin
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Meprobamate/aspirin Historical reference only Brand name in source：Equagesic
Douglas Ong · Slide 7 · Musculoskeletal chart
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Raloxifene hydrochloride Historical reference only Brand name in source：Evista
Douglas Ong · Slide 7 · Musculoskeletal chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Piroxicam Historical reference only Brand name in source：Feldene
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Etodolac Historical reference only Brand name in source：Lodine
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Meloxicam Historical reference only Brand name in source：Mobic
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Motrin
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nabumetone Historical reference only Brand name in source：Nabumetone
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Fenoprofen calcium Historical reference only Brand name in source：Nalfon
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Naproxen Historical reference only Brand name in source：Naprelan
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ketoprofen Historical reference only Brand name in source：Oruvail
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Lansoprazole/naproxen Historical reference only Brand name in source：Prevacid Naprapac
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Probenecid/colchicine Historical reference only Brand name in source：Probenecid + Colchicine
Douglas Ong · Slide 7 · Musculoskeletal chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Methotrexate sodium Historical reference only Brand name in source：Rheumatrex
Douglas Ong · Slide 7 · Musculoskeletal chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Salsalate Historical reference only Brand name in source：Salsalate
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Carisoprodol/aspirin/codeine Historical reference only Brand name in source：Soma Compound w. Codeine
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac sodium Historical reference only Brand name in source：Voltaren
Douglas Ong · Slide 7 · Musculoskeletal chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Tositumomab Historical reference only Brand name in source：Bexxar
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Bicalutamide Historical reference only Brand name in source：Casodex
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Leuprolide acetate Historical reference only Brand name in source：Eligard
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Estradiol Historical reference only Brand name in source：Estrace
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Abarelix Historical reference only Brand name in source：Plenaxis
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Bexarotene Historical reference only Brand name in source：Targretin
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Thalidomide Historical reference only Brand name in source：Thalomid
Douglas Ong · Slide 7 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Triptorelin pamoate Historical reference only Brand name in source：Trelstar
Douglas Ong · Slide 8 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Methotrexate Historical reference only Brand name in source：Trexall
Douglas Ong · Slide 8 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Histrelin acetate Historical reference only Brand name in source：Vantas
Douglas Ong · Slide 8 · Cancer chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Benzphetamine Historical reference only Brand name in source：Didrex
Douglas Ong · Slide 8 · Nutrition chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Megestrol acetate Historical reference only Brand name in source：Megace ES; Megace Suspension
Douglas Ong · Slide 8 · Nutrition chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
All oral contraceptives Historical reference only Brand name in source：All oral contraceptives
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
All hormone replacement therapy Historical reference only Brand name in source：All hormone replacement therapy
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Advil
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Naproxen sodium Historical reference only Brand name in source：Aleve
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Norethindrone Historical reference only Brand name in source：Aygestin
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Povidone-iodine Historical reference only Brand name in source：Betadine douche
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： Vaginal douche
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Urofollitropin Historical reference only Brand name in source：Bravelle
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac potassium Historical reference only Brand name in source：Cataflam
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Celecoxib Historical reference only Brand name in source：Celebrex
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Cetrorelix Historical reference only Brand name in source：Cetrotide
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Clomiphene citrate Historical reference only Brand name in source：Clomid
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Medroxyprogesterone acetate Historical reference only Brand name in source：Depo-subQ provera
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Micronized progesterone Historical reference only Brand name in source：Endometrin
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： Ectopic pregnancy
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Metronidazole Historical reference only Brand name in source：Flagyl
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 1st trimester for trichomoniasis
Selected update · checked 26 Oct 2026 CDC guidance recommends testing and treating symptomatic pregnant patients with trichomoniasis regardless of pregnancy stage. Do not apply the old first-trimester prohibition without current clinical review.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ganirelix acetate Historical reference only Brand name in source：Ganirelix acetate
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Follitropin alfa Historical reference only Brand name in source：Gonal-F
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Leuprolide acetate Historical reference only Brand name in source：Lupron Depot
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Lutropin alfa Historical reference only Brand name in source：Luveris
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Menotropins Historical reference only Brand name in source：Menopur
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Midol Cramp
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Acetaminophen/caffeine/pyrilamine Historical reference only Brand name in source：Midol menstrual
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Acetaminophen/pamabrom/pyrilamine Historical reference only Brand name in source：Midol PMS
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Acetaminophen/pamabrom Historical reference only Brand name in source：Midol teen
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Mifepristone Historical reference only Brand name in source：Mifeprex
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Motrin
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Naproxen Historical reference only Brand name in source：Naprelan
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Choriogonadotropin alfa Historical reference only Brand name in source：Ovidrel
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Mefenamic acid Historical reference only Brand name in source：Ponstel
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Follicle-stimulating hormone/luteinizing hormone Historical reference only Brand name in source：Repronex 150 IU
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Sulfamethoxazole/trimethoprim Historical reference only Brand name in source：Septra
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 3rd trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Clomiphene citrate Historical reference only Brand name in source：Serophene
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Nafarelin Historical reference only Brand name in source：Synarel
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Tinidazole Historical reference only Brand name in source：Tindamax
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Source restriction (original)： 1st trimester
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Goserelin Historical reference only Brand name in source：Zoladex
Douglas Ong · Slide 8 · Obstetrics / gynaecology chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Advil; Advil Migraine
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Naproxen sodium Historical reference only Brand name in source：Aleve
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Aspirin Historical reference only Brand name in source：Bayer
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ergotamine tartrate/caffeine Historical reference only Brand name in source：Cafergot
Douglas Ong · Slide 8 · Pain / fever
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diclofenac potassium Historical reference only Brand name in source：Cataflam
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Celecoxib Historical reference only Brand name in source：Celebrex
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Oxycodone/ibuprofen Historical reference only Brand name in source：Combunox
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Dihydroergotamine mesylate Historical reference only Brand name in source：D.H.E. 45
Douglas Ong · Slide 8 · Pain / fever
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Propoxyphene hydrochloride/aspirin/caffeine Historical reference only Brand name in source：Darvon Compound
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Diflunisal Historical reference only Brand name in source：Diflunisal
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Acetaminophen/aspirin/caffeine Historical reference only Brand name in source：Excedrin Migraine
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Butalbital/aspirin/caffeine Historical reference only Brand name in source：Fiorinal
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Butalbital/aspirin/caffeine/codeine phosphate Historical reference only Brand name in source：Fiorinal w. Codeine
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ketorolac Historical reference only Brand name in source：Ketorolac
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Etodolac Historical reference only Brand name in source：Lodine
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Dihydroergotamine mesylate Historical reference only Brand name in source：Migranal
Douglas Ong · Slide 8 · Pain / fever
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Ibuprofen Historical reference only Brand name in source：Motrin Migraine Pain
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Oxycodone hydrochloride/aspirin Historical reference only Brand name in source：Percodan
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Mefenamic acid Historical reference only Brand name in source：Ponstel
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： Late pregnancy
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Dihydrocodeine bitartrate/aspirin/caffeine Historical reference only Brand name in source：Synalgos-DC
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Pain-relief aspirin and prescribed low-dose aspirin have different uses. Do not stop prescribed low-dose aspirin because of this historical table.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Hydrocodone bitartrate/ibuprofen Historical reference only Brand name in source：Vicoprofen
Douglas Ong · Slide 8 · Pain / fever
Source restriction (original)： 3rd trimester
Selected update · checked 26 Oct 2026 Current systemic NSAID advice starts at 20 weeks, not just the third trimester. Do not use the old B/B/D classification as clearance. Formulation matters.
Current source ↗ Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Dutasteride hydrochloride Historical reference only Brand name in source：Avodart
Douglas Ong · Slide 8 · Urogenital chart
Source restriction (original)： Avoid handling capsules
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Alprostadil Historical reference only Brand name in source：Caverject; Edex
Douglas Ong · Slide 8 · Urogenital chart
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source
Finasteride Historical reference only Brand name in source：Proscar
Douglas Ong · Slide 8 · Urogenital chart
Source restriction (original)： Avoid handling crushed/broken tablets
Original statement and legacy category Historical source statement; not current advice:
Listed in the historical contraindication chart; this is not a newly verified contraindication. Legacy category No individual letter assigned here; listed in a historical contraindication chart Placental passage in source Not stated Breastfeeding Not assessed in this source Index: slides 2–6 contain 26 table entries; slides 7–8 contain 158 grouped chart entries. Repeated products under different headings are retained with their source page. Slide 1 is a title page. English source text is preserved to avoid hiding qualifiers in translation.